Acute generalized exanthematous pustulosis - Pustulose Exantematosa Aguda Xeneralizada
A Pustulose Exantematosa Aguda Xeneralizada (Acute generalized exanthematous pustulosis) (AGEP) é unha reacción cutánea rara que no 90% dos casos está relacionada coa administración de medicamentos. A pustulose exantematosa aguda xeneralizada (acute generalized exanthematous pustulosis) caracterízase por erupcións cutáneas súbitas que aparecen de media cinco días despois do inicio da medicación. Estas erupcións son pústulas, é dicir, pequenas erupcións vermellas brancas ou vermellas da pel que conteñen material turbio ou purulento (pus). As lesións cutáneas adoitan resolverse dentro de 1-3 días despois da interrupción do medicamento.
☆ Nos resultados de Stiftung Warentest de Alemaña de 2022, a satisfacción dos consumidores con ModelDerm foi só lixeiramente inferior á das consultas de telemedicina pagas.
Aparecen de súpeto lesións xeneralizadas con eritema e pústulas.
References
Acute generalized exanthematous pustulosis (AGEP) é unha reacción cutánea marcada por pequenas protuberancias cheas de pus sobre unha base da pel vermella. Adoita ocorrer cando alguén toma certos medicamentos, como antibióticos, e se espalla rapidamente polo corpo. Despois de deter o medicamento desencadeante, os síntomas adoitan desaparecer en dúas semanas, e moitas veces deixan algo de pel. Aínda que normalmente non son graves e se limitan á pel, os casos graves pódense clasificar xunto con outras reaccións cutáneas graves como Stevens-Johnson syndrome ou toxic epidermal necrolysis. O tratamento é principalmente coidados de apoio, e o prognóstico para a resolución completa da enfermidade adoita ser excelente.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Un home de 76 anos acudiu a urxencias porque a súa pel cambiou nos últimos dous días. Os médicos atoparon manchas vermellas e zonas elevadas no seu tronco, brazos e pernas. Co paso do tempo, estes parches uníronse e desenvolveu protuberancias parecidas a espiñas nas áreas vermellas. As probas mostraron un alto reconto de glóbulos brancos con moitos tipos chamados neutrófilos e un aumento dos niveis de C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
